毒性作用试验数据编号
9 |! \* r7 j" E* Q毒性类型3 d; c2 z- _& C4 i' \
测试方法
6 t, ?9 s2 }( k" K; V7 y8 ~测试对象4 F; s- P: x# j3 ]: D: M
使用剂量
5 C/ L2 o- i7 z* R毒性作用
, z* J) X' F% X
; ^, f. ^1 J- I) Z1
7 ~" F. S u d1 n
acute) n1 i0 i3 \% k+ D/ N6 b5 d
Inhalation
; L# ]! {, _# \/ K1 U
Human
/ k* Y/ \$ F! Q# V
2000 ppm/7H% c) E. f! L5 { z" m
1.眼毒性Sense Organs and Special Senses (Eye) - effect, not otherwise specified7 R* l, ~0 q9 ~' t
2.行为毒性Behavioral - hallucinations, distorted perceptions
7 g2 M, ?2 o( x
z" R" M6 u. P; E2 S) [2- c$ H/ e# j6 u$ s- L7 R- \( O
acute
; b( v0 w9 |3 |9 L
Inhalation
- n0 `4 K C& x7 V \$ w
Human+ S$ Z* B$ Z' H: ?& P" W# B
8000 ppm
, f6 q) ?+ u0 r2 r, k/ o7 }: v. Y
1.眼毒性Sense Organs and Special Senses (Eye) - visual field changes
: a1 c- o7 o. o2.眼毒性Sense Organs and Special Senses (Eye) - conjunctive irritation( z7 V' Z. {7 R$ }* |
3.肺部、胸部或者呼吸毒性Lungs, Thorax, or Respiration - cough# L5 T, R2 Q( W0 O4 p) N$ p) m" A
5 i8 V+ D( B6 r% r8 ^4 x% r30 @. z; Y! o `
acute3 i/ J# | A4 c; `
Oral
% N" U; C$ B5 l
Rodent - rat
) t# x' y4 t1 Z f5 D5 H
5480 mg/kg1 ^- `% h/ H8 B4 `
1.Details of toxic effects not reported other than lethal dose value; ]; K Q5 O2 T, e. U ^ A
4 W: X( W' u$ {% ~( k
4
( U6 U* p: ?* ~9 O
acute9 u9 U: p: K: y# Q5 J& T
Inhalation7 Q( |' y+ i2 S- J! x; n
Rodent - rat
1 b8 i2 Q% Y/ B
285 gm/m3/4H. ]2 @# v( ^# C! D5 a1 n
1.行为毒性Behavioral - general anesthetic. H7 ?6 C5 {, @* U
2.肺部、胸部或者呼吸毒性Lungs, Thorax, or Respiration - respiratory depression
+ I; w2 j& B# G5 |
% ` }- q4 J# ^! I$ e' o
58 h/ ?1 w8 }$ T$ Q7 M4 |# `
acute
; w1 m1 N9 ~& [& O4 h8 G# \2 T( f
Oral
# I$ c8 n7 L; U2 r6 ^
Rodent - mouse
" C% h G, M; h4 I7 X' i1 f4 t
3210 mg/kg
2 ~1 G2 {9 k% O5 u- z& _
1.Details of toxic effects not reported other than lethal dose value
4 a3 k& ~- l% l8 l& @
9 C7 O" o- ?% [: S. f3 P2 S& z6/ r1 R6 m( T, y& h
acute
P7 M7 U* z3 J5 r
Inhalation$ J) X. k. o* a0 y- Y+ m" f! X
Rodent - mouse
: ^. S" d" T2 c! e
270 gm/m3/2H
1 F; i: C2 y3 J4 m% D' R5 P, U/ L
1.Details of toxic effects not reported other than lethal dose value
+ ~( c8 Q; w- G
& I7 T) ?3 L# V, s7 b; P' C" k) U72 r5 }/ r. A, m( q3 ]+ g
acute
: P5 I) b( L' o
Inhalation
3 u/ G# W O5 R0 I
Rodent - rabbit' C. ]5 ~1 A5 S4 C! f I6 O
25 pph/23M
. A. i% F/ Q. u* A# V; V3 p" m
1.眼毒性Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation)5 {/ f+ _( y$ J b+ @! S2 u
2.行为毒性Behavioral - tremor
+ t4 S: k+ d6 P1 v' B. M/ s3.行为毒性Behavioral - muscle weakness' [3 c, l/ S3 s4 T/ y, k) `
9 Z. t' J8 r4 B! H# S: w- |* g. z% Z8# S, N Z r0 G4 i+ z, t
MutipleDose
. F' n& Z* G N
Inhalation
) k* s' a1 t+ h& I& V" {
Rodent - rat; B0 X$ e2 y2 ]4 t) K
1000 ppm/6H/13W-I
4 A- Z3 D7 b4 h( J' o, C7 o
1.肝毒性Liver - changes in liver weight
9 a3 V3 ~/ H8 o( h; S3 _4 @2.肾、输尿管和膀胱毒性Kidney, Ureter, Bladder - changes in bladder weight2 `& o2 z& X; Q: C5 o- t; |
" r7 @8 x# t/ h& V1 [# F9
5 g# C9 T5 \7 z. i3 {8 b
MutipleDose- U* L) u; P% V# T% i
Inhalation3 D5 v7 X0 t6 v5 [+ `6 t) x+ F. a
Rodent - rat) u8 S' @- e" h, [3 O+ i
1000 ppm/6H/1Y-I7 y9 U1 b* `9 K/ [! H) J o" `, ?2 R
1.肝毒性Liver - changes in liver weight
8 c" |2 B* { h1 Y2.慢性病相关毒性Related to Chronic Data - death
- o8 O$ r: }/ K( D$ [% }% B# {
/ n. {! f( v8 C
10
) c% \/ _4 ~+ h4 `+ v: f; z2 P9 A
MutipleDose
- W. M9 U" c' \5 s
Inhalation- N/ n8 a$ O( l# Z2 H1 w+ O( D6 V
Rodent - rat' V4 n6 z9 U3 F( Q, }7 n. \
2200 mg/m3/4H/17W-I& c# a n1 i, K" ~; f
1.血液毒性Blood - leukopenia
5 I8 J% I( M5 q1 x1 {! E- n2.生化毒性Biochemical - Metabolism (Intermediary) - lipids including transport
% ]" W( ?& T5 n V2 |! e3.生化毒性Biochemical - Metabolism (Intermediary) - other proteins# ~, [9 p# a; h" i8 `6 ~/ {
; t; ~9 v' f! p3 V" ?5 q: o! F
11& R+ H; [' u0 M6 F% o7 m
MutipleDose5 P4 O8 ^" T6 L! N
Inhalation8 [5 R0 B) X: R% _
Rodent - rat
) v) L: \/ g" H" A* p: X0 Z, W
8000 ppm/6H/2Y-I
3 c: u- p8 Z9 J% d! L
1.行为毒性Behavioral - ataxia- |2 S- D; T( p# A
2.肾、输尿管和膀胱毒性Kidney, Ureter, Bladder - changes in bladder weight. I3 {' F8 Z a4 L, l* k9 Y9 `" C/ F
3.慢性病相关毒性Related to Chronic Data - death& ?9 M# `; }7 y4 X9 H
- Y W$ O" t" E! z) D; l
12; d, ~. n$ p. Z) F& C: f
MutipleDose) E6 I* F3 P; U( ^3 u
Inhalation
! W3 L) H9 m3 p4 g A& Q# n
Rodent - mouse
/ J+ ?. R) |: P& F2 }/ v2 J
1250 ppm/6H/14W-I: u4 }& x" ]$ ~, s; D3 L2 A2 P$ J
1.慢性病相关毒性Related to Chronic Data - death
6 `& M( B* X- K3 o0 @' U
. b6 B6 w& H) @+ |8 Z13+ s, Z: `( S! |. h1 o+ \
MutipleDose* u v* p- ^" V4 I: Y8 \8 v- l( {8 _7 _
Inhalation
0 r" v/ t8 F$ D
Rodent - mouse
0 ?) l$ t( j( B9 I( h
1250 ppm/6H/6W-I
- u5 L2 T* u0 ~$ x
1.血液毒性Blood - normocytic anemia
7 \# z2 E/ x- C4 k. ]) E. I% n W, s2.血液毒性Blood - changes in bone marrow (not otherwise specified)7 L r8 c/ E6 c5 v. z
3.血液毒性Blood - changes in erythrocyte (RBC) count. W+ L8 O" M# `# ^/ e2 }
4 r! X3 g+ v2 V9 i14. P0 h/ `) u) [- ~3 k4 Y# A
MutipleDose V6 u% R1 |- D" R" j1 M1 e
Inhalation( w$ D4 f# o8 ~3 z# s4 o1 E
Rodent - mouse
( Q4 z" J/ [" E# D; A3 G
1250 ppm/6H/24W-I
( A0 e& U$ P1 k2 S
1.血液毒性Blood - pigmented or nucleated red blood cells
# l$ L3 _. r1 j/ |6 }" Y( A" N; U2.血液毒性Blood - changes in erythrocyte (RBC) count/ {) `- M! @4 p# i% R9 U9 G
3.血液毒性Blood - changes in leukocyte (WBC) count
: C+ t8 l( f; G: J
* F5 v% e3 n$ Z15 a6 t* E7 x" v1 G0 I6 y
MutipleDose
$ U8 `2 Z3 ]# D
Inhalation
7 G- r* R; m, O# `
Rodent - mouse
$ q* y# g0 Y7 v) B; D" w
8000 ppm/6H/15D-I
) V% T1 O) O- b/ Q& K
1.营养和代谢系统毒性Nutritional and Gross Metabolic - weight loss or decreased weight gain
# N7 g& S9 q0 v3 b0 x
, _( R; D4 U6 Z# g3 I16
9 e& q# P- v. {: o5 e2 ~
MutipleDose* n9 P/ Y |- |% R: m
Inhalation
, G9 N; d- ^% N# X
Rodent - rabbit; }2 [! I" F) B- o
100 mg/m3/4H/17W-I J9 u$ ~8 t6 u5 j C& O
1.免疫系统毒性Immunological Including Allergic - decrease in cellular immune response$ C& s/ U5 f* O9 k& _& R9 ]+ z) }
2.生化毒性Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase8 q1 n& ^* C+ [! p& n) p2 U
% S0 A; q6 `$ l
17
$ v& Z' o& s0 y) n5 ]
Mutation
. Y) b) \1 G& g1 w7 o) w1 c
Bacteria - Salmonella typhimurium
9 }7 O! v8 V% o# v
20 pph/20H (Continuous) b! |' V3 C0 |* N
2 F; p) ^9 r% l$ ?- ?' U$ q18" }3 }0 L* O2 X- j4 j$ g
Mutation: S# S8 _. R7 l$ e# ?
Bacteria - Salmonella typhimurium# d5 L, z1 E6 A+ A5 @
2 pph
, q1 g2 [; ~4 R6 f* g
* w* f3 m- S o19
9 O H u) u* O8 r4 r% K ^) W
Mutation
0 l- S* e8 |# w, r/ ~8 {6 u7 Q
Human Lymphocyte
/ S# }% Y. B) U( }# G& d
500 umol/L
: H! @, {7 ^2 x1 d Q
/ D4 s$ o- h3 e+ _4 v" y20& l! Q8 s0 [7 r4 d
Mutation% n" A: C) e) Z6 p, ~
Inhalation
- h0 I$ K9 {" M
Rodent - mouse( M- c4 ?3 \# w4 ^* S6 m) V8 Z
6250 ppb/6H/13W (Intermittent)
7 @" t! `+ ]8 V
0 f$ E6 n6 p/ R, L- Z( _
21
% \$ _* H' h2 r' D
Mutation4 D% T: u4 k& v! _- C
Inhalation
* R' F/ w( F' I j
Rodent - mouse0 l( a% B, \: G' C4 e
500 ppm/6H/5D (Continuous)
- @0 D Q2 M( P+ x) ]' g+ o) q8 Z
4 [& w, A; ^ _& h( g% T6 O, B4 u
22! l* W* W2 B* N5 n# R* Z) Y$ \. [2 u
Mutation
, z( o; I# g9 k, ]
Inhalation
) B- I: x4 `3 U/ }& m9 u
Rodent - mouse" b- S4 U4 [) L3 }) q
125 ppm/6H (Continuous)
4 W+ n0 u( j' p8 _$ C' f/ W
# a/ `/ k2 |( S& S g! o$ r23. S* U! c' W; r p5 @$ a: J
Mutation
- D. s/ q: M' S, M
Inhalation
% {5 ^) y+ x7 D/ r4 n/ | W Z
Rodent - mouse
2 A' s7 S7 A' s" _$ a$ K/ f
200 ppm/5D/6H (Continuous)
8 M% q1 c, R3 C2 o, q; N- O2 b
$ c& _8 e9 \, T( e! }7 D4 B5 O- e" T24
& ?' R9 z+ b6 n
Mutation
/ ^* p' q6 U+ a& k5 n
Inhalation6 F. ~7 ^" N* O$ u: J
Rodent - mouse
' K6 W7 n3 r+ P# V
625 ppm/6H/10D (Intermittent)6 `! J: [0 n1 ~, o# q* X
' ^4 B0 I( f) G2 m0 @' K3 n
25
. r" R. N h ^& \5 G7 F5 @9 b
Mutation! X g/ o! O: E% {6 B
Inhalation
2 y2 ]8 Z/ z) `4 ]) _& q
Rodent - mouse/ P! h6 S+ |4 ]" r; j$ W4 ~
6250 ppb/6H/10D (Intermittent); D! @7 o, ^+ A) S9 Z4 H. y
: Y, s* \$ r# k! i26
1 i( d5 t Z. q" n! H: U& m, D
Mutation
- r" N; V W! R# |
Inhalation6 m! i( c3 e& X! t8 d
Rodent - mouse
0 k+ O* S0 o/ W' X% E0 c
1250 ppm/6H/10W (Intermittent)
- b4 X2 W; a2 Z% V, x
# v6 G+ b0 ~" N7 H
27
; v# I: l, K- A9 a" T+ k
Mutation5 K) _+ [% D$ k5 J
Rodent - mouse Lymphocyte
: h. b8 w0 ^+ y7 K
20 pph: l/ s, I& p5 z1 K
7 Z2 i/ z3 G8 f; u
283 }% V. K' T( e* m7 ?* J" M7 D' Z
Mutation
; a& j6 W9 x, z. S
Inhalation
7 i: u' _0 c! D9 @$ z
Rodent - mouse
" z1 V' I% ~7 h! r. r( q
625 ppm/6H/2W (Intermittent)
8 `6 f) o& g) b P7 f) |
+ t4 `: [9 a, [. H9 @( B
29. X. _% [+ i9 `$ x- g9 Q
Mutation) Q& }+ ^2 n7 [
Inhalation
% t( `; |5 A, p( |; ], E
Rodent - mouse
$ _# K# a: H3 T% v. b
130 ppm/5D/6H (Continuous)
9 k3 l, Q5 N" }. n/ ^0 ^: X7 S
# Z8 p7 U* D4 h+ {5 H: @0 |30
, f8 `( ^! M& G7 T, D
Mutation
F9 W+ }2 p% c; r- j" i4 D9 C
Inhalation
3 o; k2 T O. h" P1 d3 X8 w" k! h: x
Rodent - mouse
5 i4 p# E. ^" U( E
500 ppm/6H/5D (Continuous)( H; e, f j; j* M% h
, {( A$ p" @/ k* u, A) @
31
. k6 f" y3 l# w5 X% B3 w
Mutation( D K' N8 g: K+ p# q( Z
Rodent - hamster Ovary3 z5 O. y$ O I* h B$ h1 {. s
25 umol/L% M, Y& I* [9 s% p5 s
2 @3 u J2 n' H4 h% x& R
32
) l# w$ q% l9 t0 |' T* h) g
Tumorigenic7 k2 v. b! x3 Q- ?. _7 W
Inhalation( J: w, W* [8 Z3 s# Y) ?
Rodent - rat
' l+ g! ^5 g$ o/ Z! Q$ `5 q
625 ppm/6H/61W( m& n) X* S; ]
1.致癌性Tumorigenic - Carcinogenic by RTECS criteria6 `# H$ I$ |$ r# D: Y# c0 w( J
2.心脏毒性Cardiac - tumors$ Z1 z7 R% G1 q/ R B
3.肺部、胸部或者呼吸毒性Lungs, Thorax, or Respiration - tumors: ^4 y- a9 G3 K( l
7 U, x% d" z6 l9 l! x; \9 q, }
33
# v& K1 ?5 n# t! P. P% M
Tumorigenic
8 t6 e8 I) ~3 e
Inhalation
& ?8 u# ^+ ~5 o4 f9 I1 a, i- S* i2 v
Rodent - mouse
8 c8 T2 ?* c, [
625 ppm/6H/13W-I+ E; C& H3 o9 o$ h3 I% r
1.致癌性Tumorigenic - Carcinogenic by RTECS criteria
4 ^. ?" {) Y7 P/ R- J2.嗅觉毒性Sense Organs and Special Senses (Olfaction) - tumors! ^7 Q, `/ X! m3 l
3.心脏毒性Cardiac - tumors6 M2 x+ g* O4 J$ g: G5 Y
. S8 }/ w5 l8 h/ V
341 \1 y- ?- y$ C" ?, b- `
Tumorigenic5 @# ^) Z8 k2 [. T2 s
Inhalation
|% W+ i+ M4 o8 `& P% `5 q
Rodent - rat3 k' ~8 v0 f+ X3 T0 f e
1000 ppm/6H/2Y-I4 \: w" n1 {) ~1 M% k _
1.致癌性Tumorigenic - Carcinogenic by RTECS criteria6 c [ f* e) {0 D& u" T
2.皮肤和附件毒性Skin and Appendages - tumors( m# m- P5 s3 k" |* v1 B0 E
5 I3 o2 k; s- G2 A
35
3 h- p6 c+ L3 E# v3 c- {" Y
Tumorigenic
3 f/ d4 B/ x3 V
Inhalation
! X7 d3 P# O5 `+ W% R
Rodent - rat
6 m9 G" U0 ]: f: R% x
8000 ppm/6H/2Y-I
1 b' E! ]: K5 o% Y. \
1.致癌性Tumorigenic - neoplastic by RTECS criteria% @( P) e# K$ V) H- \: b9 W* }
2.胃肠道毒性Gastrointestinal - tumors+ X+ f0 P: I5 _ e4 F, g' z
3.内分泌毒性Endocrine - thyroid tumors5 x3 g, {& x, |
% R; e' X, q' M4 K- N9 S36
9 T) \" `! @9 X4 C2 L- a
Tumorigenic
7 M9 j- @* A3 _; i1 l% H1 i
Inhalation
+ [" N% X) u" C A( p6 t$ a% I5 @% F2 Y
Rodent - rat
! t. Q, M/ `. z$ U& h# r* f
8000 ppm/6H/15W-I
: ?2 Y9 a+ ]2 m5 j! \" D
1.致癌性Tumorigenic - Carcinogenic by RTECS criteria$ s- ?- w( y6 b! {* Z/ J+ ?
2.内分泌毒性Endocrine - tumors: K; |5 A3 q* C/ u
0 N% m8 I' r: H# B1 q' [' S5 O' P! N377 [5 s) D4 z i& C- ^0 ` H
Tumorigenic, P5 {( ?! d2 u/ U5 b
Inhalation4 M8 y5 p; n2 b5 y* w3 q: `
Rodent - mouse
; _- @/ {8 R- r0 d
200 ppm/40W-I
: _0 ]% _ ^/ s
1.致癌性Tumorigenic - equivocal tumorigenic agent by RTECS criteria$ _" n# Z6 j+ |4 s: V; F( p
2.胃肠道毒性Gastrointestinal - tumors) A% K- g: m; O
: { `2 c8 @6 Z# M! N* l38
& h$ R5 Y& v( V( F7 ~/ W0 I, C$ T; z
Tumorigenic
# m& ~: o8 G" n, A& E# h/ F8 x1 l7 j- e
Inhalation2 ?$ o6 d; a( r3 V( p$ o
Rodent - rat1 B3 W8 F; M) L6 g6 L0 s
8000 ppm/6H/2Y-I" m0 `7 p9 \4 a/ q" l
1.致癌性Tumorigenic - Carcinogenic by RTECS criteria; J. x) {8 p* m" I
2.内分泌毒性Endocrine - thyroid tumors- Y! R' w$ r6 t6 E5 A" q% Y
3.皮肤和附件毒性Skin and Appendages - tumors
/ m5 w" a# s9 R& n7 V+ Q `
) u7 O: [% Q# k2 [
39; J$ s j% P- }3 d0 \
Tumorigenic1 l* }+ O! _) X. l t/ }
Inhalation5 e5 B/ H# i. D6 h" e, X2 o3 {
Rodent - mouse. u9 r) x2 Y7 w/ t5 w b
625 ppm/6H/65W-I
/ c* p4 p& B6 M$ o0 O: u) Z- i
1.致癌性Tumorigenic - equivocal tumorigenic agent by RTECS criteria; K. X' Y% c" C8 |
2.眼毒性Sense Organs and Special Senses (Eye) - tumors
- m( c) ]: J) l4 Q' [2 ^3.心脏毒性Cardiac - tumors. K* N5 K' ~' X5 k# \1 s3 X
- G# c6 R c/ e' B2 H- P
40% i0 D% |2 x( D. P$ v' s
Tumorigenic
% P1 ^2 w1 H- b O
Inhalation% \; ~4 E& V; _( l
Rodent - mouse
- R6 `/ t' ]' S
63 ppm/6H/2Y-I
/ j7 Y8 S1 E1 { |0 |, {) Z8 G
1.致癌性Tumorigenic - Carcinogenic by RTECS criteria. Z; Q B" H+ l6 Q8 Q; S
2.血管毒性Vascular - tumors8 y" k& d" W; a( z$ U! k
3.肝毒性Liver - tumors
: E* ]5 `5 A% Q8 W: ~. y9 S
0 Q) n- J7 Q9 k' B! [41+ M& R# {; R' k/ D* m8 y5 E P5 S$ K2 A
Reproductive
" G) j. H" x; ]' a5 r# L& ?
Inhalation
+ r3 ]) x- R* C" S
Rodent - rat
. z, t. q4 D" e( d
8000 ppm/6H,female 6-15 day(s) after conception* p3 F6 \! W+ `+ G4 o$ R/ Q
1.生殖毒性Reproductive - Specific Developmental Abnormalities - musculoskeletal system/ M$ r/ a0 d$ ~
0 P3 U' e# n( @8 V( _5 D$ C
42
n& U; U& q3 v7 ^- q D
Reproductive
) |0 }/ U+ ~& Q B4 {. e R
Inhalation6 d# v, T4 C( Y t( r
Rodent - mouse8 R- J8 R# H Y5 |
500 ppm/6H,male 5 day(s) pre-mating
0 h3 Z. h3 R" s1 S6 m1 M
1.生殖毒性Reproductive - Paternal Effects - testes, epididymis, sperm duct
7 _8 \5 [$ k* G& [; {2.生殖毒性Reproductive - Effects on Embryo or Fetus - cytological changes (including somatic cell genetic material)
/ \, c- P, o0 Q% `( t. A1 a
/ U0 V! o, u: t7 d* j
43
8 g0 M2 W; z0 |& k6 ?" n
Reproductive
* Z1 V0 t" z q) \* b2 _) C
Inhalation' l* D. O% s5 L* M: X
Rodent - mouse
& B+ |% g$ h) S: S8 T7 \" Y
1000 ppm/6H,female 6-15 day(s) after conception6 a; `8 U V4 m" S! [' M/ H, i, o
1.生殖毒性Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)! V+ g; A- i; D- k3 K
2.生殖毒性Reproductive - Effects on Embryo or Fetus - extra-embryonic structures (e.g., placenta, umbilical cord)
1 m) _/ W+ J. _7 W3.生殖毒性Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
. c/ l- E% q( s
4 ]5 R- `1 C! a. C: m' Y44. H# C5 X; i& M! H4 F" B w9 {
Reproductive
, h& G+ V$ A# V: P2 h; k
Inhalation: X5 b) t% ^1 Y6 Q' L$ H [
Rodent - mouse& B0 r3 N( C- U- N" O. L; h
1000 ppm/6H,female 6-15 day(s) after conception4 {- T; P) n. T1 `
1.生殖毒性Reproductive - Maternal Effects - uterus, cervix, vagina
+ W6 a! Q0 u; s
[9-46]9 Z! Y4 @+ [8 {+ F
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